Lozowski has been part of Saracens’ hugely successful era this century, winning three Premiership titles and two European Champions Cups.
He also spent a year on loan with Montpellier when Saracens were relegated to the Championship for salary cap breaches and helped the French club to success in the European Challenge Cup.
“I think at this stage in my career I need something new to sink my teeth into,” said Lozowski.
“I want to enjoy my rugby, but the Sale owners, coaches, players and fans want to win trophies and that’s really important to me too.”