Without Cummins and Hazlewood, Australia could field an unchanged attack for the pink-ball Test.
In Perth, left-armer Mitchell Starc took 10 wickets and was named player of the match. He was joined by fellow seamers Scott Boland and debutant Brendan Doggett, along with all-rounder Cameron Green and off-spinner Nathan Lyon.
Lyon struggled in Perth after being struck while batting by England fast bowler Mark Wood. If Australia decide to omit their frontline spinner in Brisbane, his replacement would be either seamer Michael Neser or all-rounder Beau Webster.
Khawaja’s place is under scrutiny after he was not fit to open the batting in either innings in Perth.
In the second innings, Travis Head was promoted from number five and struck one of the all-time great Ashes hundreds to lead Australia to victory.
If Khawaja is left out on his home ground, it would leave the door open for Josh Inglis, who made a hundred for a Cricket Australia XI against England Lions on Monday.
Australia have not lost an Ashes Test in Brisbane since 1986. They have lost only one of their 14 previous pink-ball Tests and have beaten England in all three Ashes day-nighters.
England opted against sending any of their first-Test XI to play in a two-day pink-ball match between England Lions and the Prime Minister’s XI in Canberra, starting on Saturday.
The tourists have arranged two extra training sessions in the run-up to the second Test.
They will return to practice at Allan Border Field on Saturday, when captain Ben Stokes is due to speak to the media.