West Ham could feasibly be relegated next Sunday – with a week of the Premier League season to go.
That would happen if Spurs beat Leeds on Monday and the Hammers lose at Newcastle United next weekend.
Spurs, who are one point above the Hammers with a game in hand, will be safe if they win two of their final three games.
After playing Leeds, they face Chelsea away and then Everton at home on the final day.
West Ham, who host Leeds on the final day, will need to pick up at least two points more than Spurs because of a significantly inferior goal difference.
Wolves and Burnley’s relegations have already been confirmed.
“We played well,” said Nuno after the Arsenal defeat.
“The character of the boys, the noise of the stadium. We knew the position that we are in and the boys gave it a proper fight.
“This is what we will try to do until the last minute of the season. Two games to go, it is our job to bounce back and fight and know that anything can still happen.
“Of course it is hard but we have been competing well, especially at London Stadium. The energy of the crowd was contagious for the boys. We’re going to give it a go. This group of players will react.”