Argentina have never beaten Ireland in Dublin but stunned the British and Irish Lions on their most recent visit to the Aviva Stadium last year.
Pumas head coach Felipe Contepomi has made three changes to his original 33-player squad as Facundo Isa, Rodrigo Martinez and Mateo Soler are late call-ups.
Captain Julian Montoya is one of a number of experienced players to return after missing out on the home defeats by South Africa and Australia in August, plus September’s draw away to the Wallabies, but they will be without the injured Santiago Grondona, Ignacio Ruiz and Joaquin Oviedo.
Argentina are also without prop Thomas Gallo and utility back Santi Carreras, who impressed in the win over the Lions.
Those recent Tests saw Contepomi preside over a depleted squad, while in the summer, they suffered home defeats by England and Scotland, but did account for Wales.
Argentina play enterprising, free-flowing rugby but their form has been mixed, making them an intriguing opening opponent.
Fiji were beaten by Scotland, England and Wales during the southern hemisphere leg, but a Test win over Japan in October marked the first game in charge for new head coach Jake White, who led South Africa to World Cup glory in 2007.
White named a 35-strong squad which includes former England number eight Nathan Hughes as one of four uncapped players, while Josua Tuisova, Jiuta Wainiqolo and Caleb Muntz are also included.
Farrell has experimented with his line-up in previous meetings. In 2024, he gave Test debuts to Gus McCarthy and Cormac Izuchukwu in a 52-17 win.
As for South Africa, they may have lost their most recent Test against Australia, but the Springboks are far from crisis mode.
A 3-1 series win over New Zealand and three impressive summer Nations Championship victories on home soil have helped them remain at the world rankings summit.
The world champions will be without some key figures in November with Cheslin Kolbe, Eben Etzebeth, Handre Pollard and Andre Esterhuizen all ruled out through injury.
However, head coach Rassie Erasmus will have captain Siya Kolisi, Pieter-Steph du Toit and Damian de Allende at his disposal.
He has also included six uncapped players in his squad as preparations for next year’s World Cup defence intensify.