Three City players – Elliot Anderson, Guehi and O’Reilly – started for England, while Rodri, who spent seven years at the club, was in Spain’s XI.
And three of those four players made significant errors at Wembley.
First Guehi was tackled by Lamine Yamal on the edge of his own box, allowing the Spain winger to drive towards goal and slot in his side’s opener.
In the second half Rodri’s late challenge on Jude Bellingham led to an England penalty, which Harry Kane struck against the crossbar after slipping.
And then O’Reilly had a pass intercepted deep in his own half which led to Alex Baena’s equaliser at 2-2.
On Friday, sources told BBC Sport City had been found guilty of breaking the majority of the 115 financial rules they were accused of breaching.
After a four-year investigation, the club were accused of a wide range of rule breaches centring around claims they inflated sponsorship revenue and made other “off the books” payments to circumvent financial rules between 2009 and 2018.
Sanctions are yet to be announced, but repercussions could include a points deduction, expulsion from the Premier League or a huge fine.
BBC Sport understands Premier League clubs are seeking legal advice about potential compensation.
England captain Kane played down any links between the charges and player mistakes, telling ITV Sport after Saturday’s game: “There was a discussion, but at the end of the day when we’re with England we kind of put club football to one side and it was no different this week.”