Just like last year and the year before, Wales’ Six Nations opener is against Scotland.
Wales had the upper hand in the Celtic clash up until 2023, but have failed to win in their past few encounters, including a sobering defeat at the World Cup.
The two sides will meet again at the Principality Stadium on Saturday, 11 April (16:40 BST).
“They’ve got to be one of our biggest rivalries,” admitted Williams.
“A few years ago it was us on top and they’ve really turned it around. They’re one of our biggest challenges and one of the games that we’re going to go after.
“We do want to write some wrongs [from the World Cup].
And Williams insists they have the calibre of players to be able to beat the Scots.
“It is a big match, but these are the big moments that we’re excited to play. This is what we want to do as rugby players,” she added.
“I wouldn’t call it a grudge match or anything, but we’re looking to beat as many teams as possible, Scotland being one of them.”
After Scotland, Wales host France at Cardiff Arms Park on 18 April before travelling to face reigning champions England at Ashton Gate a week later.
A trip to Belfast follows to take on Ireland after the fallow week before Wales finish their campaign back at the Arms Park against Italy on 17 May.