After the big talk in the build-up, Ireland blew France away in the opening 40 minutes but, largely, were left unrewarded for their efforts.
Cliodhna Moloney-MacDonald crossed for Ireland but had two efforts chalked off, while Brittany Hogan and Fiona Tuite were also denied first-half scores.
France, who are tipped to meet England in a Grand Slam decider on the final day of the Six Nations, showed a clinical edge and moved clear after the restart through Carla Arbez, Anais Grando and Lea Champon, while Ireland could not back up their first-half performance and fell short.
Under head coach Scott Bemand, Ireland have moved up to fifth in the world and stunned New Zealand and Australia in 2024, but the elusive Six Nations scalp goes on.
England had too much on the opening day, when a slow start was punished, and defeat by France shows there is still work to be done.
“In these kinds of Test matches the margins become finer, so we’re after finer margins than we were,” Bemand said.
“Nail your kick to touch and nail your exit – they are the type of things that don’t let France in.
“We will keep going after the finer margins and keep trying to get better. I’ve got a group who is up for that.”