Scotland fly-half Helen Nelson, who ranks fourth highest for the number of kicks out of hand in the English top-flight, may well look to exploit space around Kildunne, while Rhona Lloyd, who will line up opposite Kildunne, has scored 11 league tries for Sale so far this season.
Elsewhere prop Maud Muir wins her 50th cap for England as she starts at tighthead in place of Sarah Bern, who is part of a set of replacements which includes 112-cap Marlie Packer and Gloucester-Hartpury’s Mia Venner.
England are hunting their eighth successive Women’s Six Nations title, but are attempting to maintain their streak without a host of names who helped them to the World Cup last year.
Number eight Alex Matthews will miss the meeting with Scotland with a shoulder injury, while earlier on Thursday it was announced that prop Hannah Botterman had joined those sidelined for the tournament with an ankle injury.
Head coach John Mitchell will hope that the enforced changes will prove the making of a next generation of players, while maintaining the Red Roses’ grip on the tournament.
However Scotland, who will play in front of a 25,000-plus crowd at Scottish Gas Murrayfield in the biggest stand-alone women’s sporting fixture in their country’s history, will be primed to exploit any wobbles.
England: Sing; Breach, Jones (capt), Rowland, Kildunne; Harrison, L Packer; Clifford, Cokayne, Muir, Burton, Ives Campion, Short, Kabeya, Feaunati,
Replacements: Powell, Carson, Bern, Lutui, M Packer, Robinson, Aitchison, Venner