While Nottingham Forest struck the first blow of the weekend on Friday, Tottenham and West Ham – unusually – both play at the same time on Saturday.
The Hammers host Everton and former manager David Moyes, with Spurs visiting already relegated Wolves.
Tottenham boss De Zerbi, whose side conceded a last-minute equaliser to draw 2-2 with Brighton in their previous fixture, said “a win can change this part of the season”.
“We are suffering, they are suffering because it is not easy to play in Tottenham in this condition of the table, but I said they have to be stronger,” he added.
“We have to live every part of the day waiting for a win and preparing for a win.”
Tottenham and West Ham have to contend with similar run-ins, with Spurs arguably facing the slightly easier of the two. The average position of the teams they still have to play is 11th, while for the Hammers it is 10th.
What West Ham do have which Tottenham do not, however, is some semblance of form.
Nuno’s team have won two and lost just one of their past five matches. Spurs have not won since last year.
“The players are improving their levels and the standards,” said Nuno. “We have been solid in defence, good in attack… sometimes not so good. Finding that balance in the remaining matches is going to be crucial for us.”