Mako Vunipola is set to make his Leicester debut against former club Saracens.
The prop starts at loose-head alongside Samiuela Moli and Joe Heyes, with Finn Carnduff partnering Cam Henderson in the second row after signing a new deal with the club.
Aaron Wainwright also makes his Leicester debut in an all-Welsh back row alongside Tommy Reffell and captain Olly Cracknell.
Freddie Steward returns at full-back, with Adam Radwan and Gabriel Hamer-Webb on the wings and Solomone Kata partnering Joseph Woodward in midfield.
Saracens captain Maro Itoje leads a visiting side packed with internationals.
Argentina international Juan Martin Gonzalez makes his full return to competitive action on his 50th Saracens appearance, while Alfie Barbeary makes his first league appearance for the club after joining from Bath.
Former Wales scrum-half Tomos Williams makes his competitive Saracens debut, with Fergus Burke at fly-half and Elliot Daly starting at full-back.
Olamide Sodeke could make his first Premiership appearance since 2025 after being named among the replacements.
Leicester: Steward; Radwan, Kata, Woodward, Hamer-Webb; Searle, Van Poortvliet; Mako Vunipola, Moli, Heyes, Carnduff, Henderson, Wainwright, Reffell, Cracknell (c).
Replacements: Thunder, Haffar, Hurd, Thompson, Moro, Whiteley, Bailey, Hassell-Collins.
Saracens: Mawi, Dan, Street, Itoje (c), Tizard, Isiekwe, Gonzalez, Barbeary; Williams, Burke, Segun, Hartley, Tompkins, Elliott, Daly.
Replacements: Clarke, Brantingham, Clarey, Sodeke, Michelow, Earl, Bracken, Malins.