Bristol have brought their Six Nations internationals – Louis Rees-Zammit, Tom Jordan and Ellis Genge – back in for their second showpiece game at Cardiff’s Principality Stadium.
The trio all return as part of six changes to the side that was narrowly beaten by Leicester last week.
Aidan Boshoff also comes onto the wing, with Gabriel Ibitoye moving to the bench, with Matias Moroni in midfield and Viliame Mata in the back row.
There are also four alterations to the Harlequins line-up as they seek a first Prem win since 25 October.
England’s Marcus Smith has dropped out of the squad, with Wales international Jarrod Evans starting at fly-half and Jamie Benson at full-back.
Prop Joe Jones and 18-year-old England Under-20 lock Elliot Williams are both set to make their first Prem starts.
Bristol: Rees-Zammit; Ravouvou, Moroni, Williams, Boshoff; Jordan, Randall; Genge, Oghre, Kloska; Dun, Owen, Luatua, Harding (c), S. Grondona.
Replacements: Gwilliam, Woolmore, Chawatama, Taylor, B. Grondona, Marmion, Janse van Rensburg, Ibitoye.
Harlequins: Benson; Isgro, Murley, Bradley, David; Evans, Townsend; Kerrod, Walker, Jones; Treadwell, Williams, Petti Pagadizabal, Kenningham, Dombrant (c).
Replacements: Riley, Hobson, Delgado, Green, Carr, Driscoll, Grant, Kerr.