Dubois fought early in the night on the prelims in front of a lightly filled Kaseya Center – the 20,000-seat home of the Miami Heat.
She walked to the ring singing along to Whitney Houston’s ‘I’m Every Woman’ and started confidently, moving in and out of range and repeatedly beating Panatta to the punch.
A straight left from the champion’s southpaw stance landed cleanly and regularly in the third round as the gap in class became increasingly clear.
“Lovely, Caroline, keep going,” shouted stablemate and former cruiserweight world champion Chris Billam-Smith from the crowd as Dubois pressed forward.
Dubois whipped a body shot into Panatta’s midriff in the fifth and again in the sixth, each drawing nods of approval from ringside.
Moments later came the knockdown. As Panatta dipped to attack the body, Dubois slipped the shot and fired a perfectly timed counter to the chin.
Panatta, 34, crashed to the canvas in a heap.
She rose quickly but looked shaken; her brief grin doing little to disguise the effect of the punch.
With little time left in the round, Panatta managed to see out the bell.
Dubois increased the intensity in the closing stages, varying her work by mixing jabs and uppercuts, while a marked-up Panatta had few answers as the champion comfortably closed out the final rounds.
It meant there was little doubt when the scorecards were read out.