Alyssa Healy began her final series before retirement with a half-century as Australia eased to a six-wicket victory over India in the opening one-day international.
She scored 50 off 70 balls opening the batting as Australia chased down a target of 215 with 11.4 overs to spare in the day-night match at Allan Border Field in Brisbane.
Beth Mooney made a fluent 76 off 79 balls before all-rounder Annabel Sutherland hit an unbeaten 48, sealing victory with a six off Deepti Sharma.
Hobart will stage the final two matches of the series, on Friday and Sunday.