Brazil defender Gabriel Magalhaes has become the latest player from title-chasing Arsenal to withdraw from international duty with injury.
Six of the Arsenal first-team squad have now pulled out or been determined to be unavailable to represent their country in the international window that begins this week.
The Brazil Football Federation (CBF) said that Gabriel will miss the friendlies against France and Croatia, which will take place in the United States, because of “pain in his right knee”.
The CBF says that imaging tests confirmed the 28-year-old’s injury.
Gabriel played the full 90 minutes as Arsenal lost 2-0 to Manchester City in the Carabao Cup final on Sunday.
His fellow Arsenal centre-back William Saliba has withdrawn from the France squad, with Les Bleus also travelling to the US for their friendly matches against Brazil and Colombia.
England midfielder Eberechi Eze was called up to Thomas Tuchel’s 35-man squad for friendlies against Uruguay and Japan but withdrew with a calf problem.
He suffered that blow in Arsenal’s 2-0 victory over Bayer Leverkusen in their Champions League last-16 second leg and missed the Wembley defeat on Sunday.
Arsenal team-mate Ben White has since been called up by Tuchel to fortify the England squad.
Gunners manager Mikel Arteta has confirmed the club are waiting for Eze to undergo another scan to find out the severity of his injury.
Arsenal winger Leandro Trossard is out of the Belgium squad for their matches against the USA and Mexico because of an injury issue.
Club captain Martin Odegaard was already ruled out of Norway duty because of a knee injury, while Dutch defender Jurrien Timber is also out of action at the moment.
Arsenal are competing to win their first Premier League title for 22 years and lead second-placed Manchester City, who have a game in hand, by nine points.
They are next in action when they take on Southampton in the FA Cup quarter-finals on April 4, before they play the first leg of their Champions League quarter-final against Sporting on April 7.
The Gunners resume their league campaign on April 11 when they play Bournemouth at Emirates Stadium.