For the last 20 years, seats in Hindley Green have mostly been won or held by Labour or independent councillors.
But, as it swept the board in May, Reform took one of the Hindley Green Labour seats.
It currently holds 25 of the 75 seats on the council. And if puts in a similar performance the next time a third of the councils seats are up, Wigan would become the first Reform-controlled authority in Greater Manchester.
But the leader of the 38-strong Labour group, Nazia Rahman, is hoping that Burnham’s June victory will help the party to win Hindley Green back.
She said: “We don’t want to take any vote for granted, but we are working really hard.
“We are running a very positive campaign and we have a very strong local candidate.
“So we are hoping that the results will be positive for Labour Party and it will set the tone for the next year’s elections.
“After Andy, I think people can see that message of hope so we are seeing a lot of positivity on the doorstep.”
Reform won Hindley Green in May with 1,878 votes. Labour came second with 1,172, and the Greens finished third on 258.
Paul Watson, the Reform group leader in Wigan, is confident his party will take it again.
He said: “I think a week’s a long time in politics, but it will be a significant indicator of the mood of the people of Makerfield in particular Hindley Green.
“I’m quite optimistic about this by-election because, looking at the data, if our voters come out we’re going to absolutely smash Labour.
“And that will really bloody the nose for the reputation of the prime minister.”