This is a painful case of deja vu for Newcastle.
It was just a few weeks ago that the club lost out on another top target, Victor Munoz, who opted to join Liverpool.
Talent identification is clearly not the issue.
Newcastle have targeted Manzambi, Munoz, Hugo Ekitike, Joao Pedro, Benjamin Sesko and James Trafford in the last 12 months.
But losing out to Aston Villa for a top target would be another real setback in the transfer market for Newcastle.
If Newcastle miss out, the big question is can the club discreetly pivot to another promising target, as they did with Bazoumana Toure after Munoz went elsewhere?
On one hand, there is plenty of time left in the window to do just that and strengthen other areas of the side.
On the other, there is a lot of work to do and little margin for any further knockbacks.
The sight of those players not involved at the World Cup returning for pre-season training on Monday was a timely reminder of that.