Wales open their campaign against Scotland, who crushed their World Cup hopes last summer in a sobering opening match.
In fact, Wales have not tasted victory over their Celtic rivals in more than three years, but George says Saturday will be far from a grudge match.
“It doesn’t matter who we’re coming up against in the first week, it’s the first game, so we really want to try and put a stamp down,” she said.
“It’s a fresh start, we’ve got new coaches coming in and a different style of playing.
“It’s the same for them, they’ve got new coaches. We don’t really know what they’re going to bring, but we’re concentrating on ourselves as much as we can. Obviously we’ll look a little bit at them, but the onus is on us.”