City are on a high after an impressive season so far but they have failed to win their past two away games.
Their explosive home win over Tottenham was the perfect response to a disappointing draw at Aston Villa the week before.
“Winning games and scoring lots of goals builds confidence. I’m happy about that and it has shown in the week,” said manager Andree Jeglertz.
“There is a great mood in the group. You know you’re surrounded by great football players so that creates confidence.
“We’re fully aware we’re playing against a very good team, who have had a great season. It will be a battle but I’m really looking forward to it.”
It will be Jeglertz’s first experience managing at Old Trafford but he says it is not something he has thought about as he prepares for the derby.
City have, however, missed playing in Europe while watching their rivals compete in the Champions League quarter-finals this week – Arsenal beat Chelsea 3-1 in the first leg of their tie.
And Jeglertz sees both “positive and negative” aspects to both side’s preparations.
“We have really missed those nights,” said Jeglertz.
“United have had the possibility to play these high intensity games during the week when we haven’t.
“We train a lot but we don’t get those games like they do. That is also building something for them and they know about the speed they will face.
“We can’t prepare in the same way so there are both positive and negative parts in not playing these games. Physically, there is definitely an advantage for us. But mentally, and in preparation, I would say it’s the same.”