Mee started against England and France in the first two rounds, but missed out against the Scots, when Hamer-Webb made his Test debut.
The Leicester wing showed flashes, but was also centre stage for the try by Darcy Graham that was created by Finn Russell’s sharp thinking from a quick restart.
The Scotland and Lions fly-half exploited the space left by former Cardiff back Hamer-Webb after he had chased Jarrod Evans’ successful penalty kick.
Murray came on for Hamer-Webb when he suffered an early nose injury and then was a permanent replacement for the final quarter.
Mee, who is strong in the aerial game, gets the nod for Dublin.
Botham came on in the first half of the game against Scotland and was an impressive performer, although he was also caught out by Russell’s restart.
Ospreys fly-half Edwards, who had started seven matches before being dropped against Scotland, will pull the strings after Costelow’s bright display was ended by an ankle injury.
Harlequins’ Jarrod Evans is again a replacement having been used off the bench five times by Tandy while not starting a Test match since 2021.
“There are a couple of enforced changes this week due to injury and then Ellis had played well in the opening couple of rounds, so we feel he deserves the opportunity again,” said Tandy.
Hennessey, who has played centre and wing for Bath, is in his second campaign with Wales after being an unused member of the squad in November 2025.
“Louie was unfortunate not to get his opportunity in the autumn, but he’s trained well,” said Tandy.
“He had a bit of a bump on his hand at the start of this campaign, but the way he’s recovered and put performances in the training environment has been very impressive. We’re all excited to see Louie go out in Dublin.”