Wales are playing a week later than other nations, with all last weekend’s games played outside World Rugby’s international window.
The window is a designated three-week period, which starts this weekend, where international matches take precedence over club fixtures and all players are made available.
The likes of Ireland, Scotland and England chose to stage matches a week before the window opened.
The extra games are organised to raise revenue for governing bodies with the success of the fixture depending on how many tickets are sold.
The Welsh Rugby Union (WRU) has opted to play their extra match on the weekend after the window closes. They take on the Springboks on Saturday, 29 November when no other international matches are taking place.
The match in Cardiff clashes with league fixtures in the United Rugby Championship (URC) which will involve sides from Wales and South Africa.
Both Test teams are set to also be without players who play for clubs in England and France, while the Springboks also have players involved with sides in Japan.