The biggest decision for Wiegman is how she will replace Williamson and Bright in defence.
Their absences in defence could be a chance for Wiegman to hand Arsenal teenager Katie Reid a first senior call-up.
The 19-year-old has been excellent so far in her breakout season, keeping fellow England defender Lotte Wubben-Moy out of the side in the process.
Wiegman could also give Manchester United captain Maya le Tissier an opportunity at centre-back in these friendlies, despite preferring her at full-back for England.
Elsewhere, she has decisions to make on the attacking front with Chelsea striker Aggie Beever-Jones continuing her impressive form with four goals in six games.
Could she be given a run ahead of Arsenal’s Russo, who has two goals and two assists in the WSL this season?
There is also an opportunity to start teenage sensation Agyemang, who burst on to the scene at Euro 2025 with crucial goals off the bench.
“She’s currently leading the line for us and there’s an expectation to score goals as the leading number nine. It’s stuff she’s learning to deal with – these new pressures,” said Brighton manager Dario Vidosic, who is working with Agyemang during her loan spell from Arsenal.
“On top of that, she has the national team. It’s a lot for a young player to take on but we’re just trying to get her to focus on her football, her development and most importantly to enjoy it as a young player.
“There is obviously natural pressures to play well but it should always be with enjoyment. It shouldn’t be a burden [to play for your country] and definitely not for a 19-year-old.”
It would be the perfect period to experiment and build experiences for youngsters, with England’s last four matches of 2025 being friendlies.
They are also only playing one team – Brazil – inside the top 10 of Fifa’s world rankings.