Having come close in the Europa League last season, David Moyes now takes his side into the Europa Conference League, boosted by fresh optimism.
While their start to the Premier League campaign has been a stuttered one at best, a raft of new signings could help Moyes balance the dual duties much better than last time out.
Indeed, the east Londoners are surely one of the favourites for the competition, now in its second year.
Last season went some way to creating new memories at the club’s still relatively new home and tonight’s game could be quite the spectacle under the lights.
Here’s everything you need to know about where to watch the game.
Where to watch West Ham vs FCSB
TV channel: In the UK, tonight’s game will be broadcast live on BT Sport 2, with coverage beginning at 7:45pm BST ahead of an 8pm kick-off, after Arsenal’s Europa League meeting with FC Zurich.
Live stream: BT Sport subscribers will also be able to watch the match live online via the BT Sport website and app.