The defender was sent off against Leeds and duly missed Saturday’s win over Leicester City at Stamford Bridge, though will return to the starting lineup for a crucial game down on the south coast.
Conor Gallagher, however, is suspended himself after picking up two bookable offences on Saturday.
That adds to a midfield selection headache for Tuchel, who namechecked young Carney Chukwuemeka as a potential option.
N’Golo Kante is injured while Mateo Kovacic is only recently making his return to the fold.
Elsewhere, Raheem Sterling will once again lead the line and his budding partnership with Marc Cucurella is set to continue at Ben Chilwell’s expense.
Predicted Chelsea XI: Mendy; Chalobah, Thiago Silva, Koulibaly; James, Loftus-Cheek, Jorginho, Cucurella; Mount, Havertz, Sterling
Injured: Kante (hamstring)
Venue: St Mary’s Stadium
Referee: Michael Oliver