The Brazilian and Cristiano Ronaldo have lifted ten Champions League titles between them but are set to play in Europe’s secondary competition for the very first time.
Indeed, the midfielder is still getting up to speed following his move from Real Madrid, while Ronaldo has been relegated to a bench role under Erik ten Hag.
It remains unclear as to whether or not Anthony Martial will be fit enough to return, although Luke Shaw could replace Tyrell Malacia at left-back as ten Hag looks to rotate.
Martin Dubravka could make his debut for the club and it will be fascinating to see whether Antony continues in attack, having scored on his debut against Arsenal.
Man United predicted XI (4-2-3-1): Dubravka; Dalot, Maguire, Lindelof, Shaw; Casemiro, Fred; Antony, Fernandes, Elanga; Ronaldo