The Belgian midfielder had also been of interest to West Ham during a frantic end to the summer transfer window.
David Moyes’ side were already in talks with the Molineux club over a potential move for Craig Dawson as the deadline approaches, with the veteran defender expected to leave the London Stadium.
Still, Villa have now had an offer believed to be in the region of around £13m accepted for the 27-year-old and his arrival comes as Arsenal target Douglas Luiz.
The Premier League leaders remain active in the market following injuries to Thomas Partey and Mohamed Elneny and the Brazilian has emerged as a leading target.
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While Villa are reluctant to sell, Luiz has only a year to go on his contract at Villa Park, meaning that stance may change during the final few hours of the window.