A late Angelino goal gave the Bundesliga side a 1-0 aggregate lead last week.
While the young German club are yet to win a major trophy, Rangers’ history is steeped in silverware and a victory in this semi-final tie would set up a chance to win their first European honour since 1972.
An Old Firm draw with Celtic on the weekend means this is the Gers only significant chance of a title this season, while Leipzig lost to Borussia Monchengladbach to leave them outside the Bundesliga’s top four.
Here is everything you need to know ahead of the game…
Date, kick-off time and venue
Rangers vs RB Leipzig is scheduled for an 8pm BST kick-off on Thursday, May 5, 2022.
Ibrox in Glasgow will host the match.
Where to watch Rangers vs RB Leipzig
TV channel: The match will be televised on BT Sport 2 and Ultimate, with coverage beginning at 7pm.
Live stream: BT Sport subscribers will be able to watch the match online via the BT Sport website or app.
Rangers vs RB Leipzig team news
Kemar Roofe could make an eagerly-awaited return to the Rangers XI having sat out the first leg defeat and Old Firm derby.
Alfredo Morelos and Iannis Hagi remain out with Aaron Ramsey a doubt due to a hamstring issue.
Leipzig have concerns over Josko Gvardiol after he came off over the weekend with an injury.
Rangers vs RB Leipzig prediction
With a raucous Ibrox backing behind them and just a one-goal deficit, Rangers can be confident of striking early once more to take this one all the way.
A 1-0 Rangers win, Rangers to win on penalties.
Head to head (h2h) history and results
Last week’s first leg victory for Leipzig was the first meeting between the pair.