A man has been arrested on suspicion of attempted murder after four pedestrians were injured after reports a car was driven on the wrong side of the road.
Police were called to Shaftesbury Avenue, in west London, at 00:45 GMT.
One pedestrian was in a life-threatening condition, Met Police said.
The driver – a 31-year-old man – was arrested on suspicion of attempted murder.
Police are treating it as an isolated incident, which is not terror related.
Deputy Assistant Commissioner Stuart Cundy said: “Detectives are quickly progressing inquiries as part of this investigation.
“It’s believed that the suspect was involved in an altercation at a nightclub prior to getting in his car and mounting the pavement.”