The England centre-back has missed the last two matches due to a knee issue but was back in training on Wednesday, along with Aaron Wan-Bissaka, who has not played since the heavy defeat to Liverpool.
It remains to be seen whether Ralf Rangnick brings the pair straight back into the fold, with the interim boss likely to take no risks with their fitness in the final two games of the season.
Jadon Sancho will definitely be unavailable against Brighton, as the winger is still suffering with tonsillitis. He faces a race to be fit for the trip to Selhurt Park on the final day of the campaign.
“If [Sancho manages to return] then maybe in the last game,” Rangnick said.
“I was in contact with him this afternoon. He was in hospital until this morning so he only returned back home today. He still doesn’t feel well so, for sure, not [against Brighton].”
Fred returned to the squad against Brentford and will be pushing for a start, while Juan Mata made his first Premier League start of the season against the Bees.
United were impressive and looked far more fluid in attack than they have done in recent months, so the Spaniard may well keep his place against Brighton.
Manchester United predicted XI (4-2-3-1): De Gea; Dalot, Varane, Lindelof, Telles; Fred, McTominay; Elanga, Mata, Fernandes; Ronaldo.