In a cagey first quarter, both sides struggled to keep hold of the ball but the Roses edged a 14-11 lead.
The Silver Ferns quickly closed that gap in quarter two as England were punished for their sloppiness and errors began to accumulate.
Head coach Jess Thirlby shuffled the attack end to try to change the momentum, Helen Housby replacing Olivia Tchine at goal shooter as England lacked the potency under the post they had shown in game two.
But the hosts could not prevent New Zealand turning the tables and taking a two-goal lead into half-time.
England rallied after the break, much to the delight of an enthusiastic home crowd, as London Pulse defensive duo Halimat Adio and Funmi Fadoju worked hard to win the ball back and Housby and Lois Pearson combined well in the shooting circle.
But the Roses let things slip in the final couple of minutes of the third quarter, losing their way and allowing New Zealand to take a 42-38 lead going into the final period.
Fadoju claimed a loose Silver Ferns pass early in the final quarter as England tried to claw back the deficit. But defensive hard work was not always rewarded with goals at the other end as New Zealand further stretched their lead.
Shooter Grace Nweke, who has enjoyed a fruitful series, was consistent under the post while Maddy Gordon shone at centre.
Thirlby made changes in attack but no combination had the desired effect and the Roses could not close the gap.
They will face Jamaica in December before taking on South Africa in January as they continue to build up to the 2026 Commonwealth Games in Glasgow.